The CARD-CARD-dependent conversation of NOD1 and RIPK2 as effectively as the homodimerization of the ASC CARD domains had been equivalent in energy, while lower then the types reported just before
Furthermore, we exposed a hitherto mysterious NOD2 conversation with NLRP3. Equivalent to the interaction of NOD2/RIPK2, we noticed NLRP3 binding to be dependent on equally NOD2 CARD domains. This finding…