Schematic representation of the recombinant EBVs generated with a deletion in the BHRF1 locus (BHLOC KO). Recombinant EBV-BACs harbouring a deletion of the comprehensive BHRF1 locus were constructed
Preceding studies showed that the EBV viral BCL-2 homologue, BHRF1, is only expressed early upon an infection of resting B cells or throughout lytic reactivation . Even though ionomycin remedy…