Expression of sZIP and ZIP was diminished in the presence of wt viruses but not when Vpr was deleted or mutated on its DCAF1 binding web site (Figures five and S5B)
A second mutant, VprS79A, which has misplaced its capacity to arrest the cell cycle in G2 , nonetheless interacted with equally sZIP and ZIP in vivo (Figure 4C) and induced…