Targets：Cathepsin inhibitors
medchemexpress products name :Sildenafil Citrate Tebipenem
Product alias :SYN-3016
Description: Sildenafil citrate is an orally active selective inhibitor of cGMP – specific PDE5 (phosphodiesterase type 5) which is the predominant PDE isoenzyme in human corpora cavernosa. Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). Sildenafil citrate acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Sildenafil has been the prime treatment for erectile dysfunction. Studies in vitro have shown that sildenafil has between 10 and 10,000-fold greater selectivity for PDE5 than for other phosphodiesterase isoforms (PDEs 1, 2, 3, 4, 6, 7 to 11). In particular, sildenafil has greater than 4,000-fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility. Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 >150 mM) [Pfizer].
cas no. : 171599-83-0
Api wt. : 474.58References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/17483510,16790841