Targets：Carbonic Anhydrase inhibitors
medchemexpress products name :Prazosin HCl ATP-polyamine-biotin
Product alias :SYN-3017
Description: Prazosin hydrochloride, a quinazoline derivative, is the first of a new chemical class of anti-hypertensives. Prazosin hydrochloride is a selective adrenergic alpha-1 antagonist used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud disease, prostatic hypertrophy and urinary retention. The exact mechanism of the hypotensive action of prazosin is unknown. Prazosin causes a decrease in total peripheral resistance and was originally thought to have a direct relaxant action on vascular smooth muscle. Recent animal studies, however, have suggested that the vasodilator effect of prazosin is also related to blockade of postsynaptic alpha-adrenoceptors. The results of dog forelimb experiments demonstrate that the peripheral vasodilator effect of prazosin is confined mainly to the level of the resistance vessels (arterioles). Unlike conventional alpha-blockers, the antihypertensive action of prazosin is usually not accompanied by a reflex tachycardia. Tolerance has not been observed to develop in long term therapy.
cas no. : 19237-84-4
Api wt. : 383.40References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/17483501