T carbon (-)-Irofulven Biological Activity emission price (yuan /kg); p BSJ-01-175 web represents of fresh products (yuan/kg); represents the demand (kg) of consumer j; q j indicates freshness loss coefficient; may be the value thefresh merchandise prospects inside the distribution network; Q represents of demand of all (yuan/kg); h represents the demand vehicle consumer ; section (i, j) within the period h; tijk represents the time for (kg) of k to travel onh dij represents the distance traveled by vehicle k around the road section (i, j) inside the time period h; si indicates the service duration for customer i. tijk represents the total time for car k to travel on section (i, j); Lik could be the point in time when automobile k leaves customer i; Xijk can be a variable of 0. Xijk = 1 when the automobile k travels around the section (i, j), otherwise Xijk = 0; h h xijk is actually a variable of 0. xijk = 1 when the automobile k travels on the road section (i, j) h within the time period h, otherwise xijk = 0; yik is often a variable of 0. When car k visits buyer i, yik = 1; otherwise, yik = 0; zk can be a 0 variable, if car k is used zk = 1, otherwise zk = 0.two.two.six. TDGVRPSTW Model Formulation The TDGVRPSTW model is built as follows: minC = C1 C2 C3 Among them C1 = (5)i N j N kKXijk Dij zk kKPc ( Tik )i NAppl. Sci. 2021, 11,eight ofC2 =h H i N j N kKh h xijk Eijk C3 = Subject to:kK j N0j pq j y jki Nqi yik Q, k K X0jk 1, k K(6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17)j NkKyik = 1, i Nj Ni NXijk = Xijk , k Kh Xijk tijk , i N, j N, k K h dijk Xijk , i N, j N, k Ktijk = Dij =h Hh HET0 Xi0k ( Tis si ti0k ) LT0 , i N , k K Tis Tik , i N , k K Lik = Tis si , i N, j N, k K t0i = Tis , i N , k Kj N h xijk 0, 1, Xijk 0, 1, yik 0, 1, zk 0, 1X0jk 1, k KEquation (5) with the objective function represents price minimization, where C1 represents distribution cost, like vehicle transportation price, car fixed use cost, and soft time window penalty expense. The time windows penalty cost is defined in Equation (4). C2 represents the cost of carbon emission and C3 represents the cost of freshness loss. Carbon emission price is defined in Equation (three), and freshness loss expense is defined in Section 2.two.two. Equation (6) represents the load limit of each vehicle. Equation (7) indicates that every single automobile can only be applied when. Equation (8) indicates that every single customer should be served only after. Equation (9) indicates that the number of departing and arriving automobiles at each node need to be balanced. Equation (10) represents the partnership amongst the road section driving time and the car driving time inside the time period. Equation (11) represents the relationship among the road section distance and the distance traveled by the car in every single period. Equation (12) indicates that automobiles returning for the distribution center should meet the constraints of the distribution center’s operating time window. Equation (13) represents the relationship among the begin time of service and also the arrival time. Equation (14) represents the partnership among the service start off time, duration, and departure time. Equation (15) indicates the time when the buyer receives the fresh goods. Equation (16) indicates that the customer’s demand is much less than the car capacity, and there’s only one automobile to serve them. Equation (17) represents the variable worth constraint. three. Variable Neighborhood Adaptive Genetic Algorithm 3.1. Algorithm Model The adaptive genetic algorithm (AGA), compared with.