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| COMMENTARYA Bitter Taste with the Sun Tends to make EggLaying Flies RunAnupama Dahanukar,1 and Chun Han,,Division of Entomology, Institute for Integrative Genome Biology, University of California, Riverside, California 92521, Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, New Dipivefrin hydrochloride YorkKEYWORDS Drosophila egg laying; UV sensing; bittersensing neurons; dTRPAIn this commentary, Anupama Dahanukar and Chun Han talk about Guntur et al. (2016) “H2O2sensitive isoforms of Drosophila TRPA1 act in bittersensing gustatory neurons to market avoidance of UV during egg laying,” which is published within this challenge of GENETICS. The study reports a new function for bitter taste neurons in TRPA1mediated sensing of DBCO-NHS ester custom synthesis bright UV and its avoidance during egg laying. EEING the light is of clear value to an animal’s life. Apart from enabling visual perception with the surrounding globe, animals have other lightsensing demands, by way of example, to regulate circadian rhythms (Yau and Hardie 2009) and to avoid dangerous light. Light within the ultraviolet (UV) spectrum may cause harm to biological tissues. Thus, it truly is not surprising that animals have evolved creative strategies to detect and steer clear of bright UV light. In an short article within this issue of GENETICS, ChungHui Yang’s group reports dTrpA1mediated detection and avoidance of UV light for egg laying (Guntur et al. 2016). Preceding research present some information regarding UV sensing. For example, the nematode Caenorhabditis elegans will not have specialized lightsensing organs, but a subset of neurons positioned around the physique can respond to UV light and elicit escape behaviors (Edwards et al. 2008; Ward et al. 2008). This ability presumably keeps the worm in the soil and prevents it from becoming injured by high doses of sunlight. Comparable nonocular photoreceptors turn out to become crucial for UV sensing in insects at the same time. The larva of the vinegar fly Drosophila melanogaster has eyelike lightsensing structures named Bolwig organs nearCopyright 2017 by the Genetics Society of America doi: ten.1534/genetics.116.196352 Manuscript received October 20, 2016; accepted for publication November 20, 2016. 1 Corresponding authors: Division of Entomology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521. E mail: anupama.dahanukar@ ucr.edu; and Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853. E mail: [email protected] head. Although Bolwig organs are tuned to detecting relatively low level of light, bright UV light like in direct sunlight is sensed by a group of peripheral somatosensory neurons situated around the physique wall (Xiang et al. 2010). The.