Name: Human F13a/Factor XIIIa Recombinant Protein (His Tag)
Synonyms: Coagulation Factor XIII A Chain;Coagulation Factor XIIIa;Protein-Glutamine Gamma-Glutamyltransferase A Chain;Transglutaminase A Chain;F13A1;F13A
Expression host: HEK293 Cells
Sequence: Gly39-Met732
Accesstion: AAH27963.1
Species: Human
Mol_Mass: 80.3 kDa
AP_Mol_Mass: 80-90 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 50 mM NaCl, 5% Sucrose, 0.3% Histidine, pH 8.0.
Reconstitution: Not Applicable
Background: Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
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