Product Name :
BACE1-IN-5
Description:
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 9.1 nM, and also inhibits cellular amyloid-β (Aβ) with an IC50 of 0.82 nM. BACE1-IN-5 has a medicinal chemistry that improves hERG inhibition and P-gp efflux.
CAS:
Molecular Weight:
461.41
Formula:
C18H16F5N5O2S
Chemical Name:
N-[3-[(4S, 6S)-2-amino-4-methyl-6-(trifluoromethyl)-5, 6-dihydro-1, 3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
Smiles :
C[C@]1(C[C@H](SC(N)=N1)C(F)(F)F)C1=CC(=CC=C1F)NC(=O)C1=CN=C(C=N1)OCF
InChiKey:
JRPAQOLQALFUAQ-GUYCJALGSA-N
InChi :
InChI=1S/C18H16F5N5O2S/c1-17(5-13(18(21,22)23)31-16(24)28-17)10-4-9(2-3-11(10)20)27-15(29)12-6-26-14(7-25-12)30-8-19/h2-4,6-7,13H,5,8H2,1H3,(H2,24,28)(H,27,29)/t13-,17-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 9.1 nM, and also inhibits cellular amyloid-β (Aβ) with an IC50 of 0.82 nM. BACE1-IN-5 has a medicinal chemistry that improves hERG inhibition and P-gp efflux.|Product information|Molecular Weight: 461.41|Formula: C18H16F5N5O2S|Chemical Name: N-[3-[(4S, 6S)-2-amino-4-methyl-6-(trifluoromethyl)-5, 6-dihydro-1, 3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide|Smiles: C[C@]1(C[C@H](SC(N)=N1)C(F)(F)F)C1=CC(=CC=C1F)NC(=O)C1=CN=C(C=N1)OCF|InChiKey: JRPAQOLQALFUAQ-GUYCJALGSA-N|InChi: InChI=1S/C18H16F5N5O2S/c1-17(5-13(18(21,22)23)31-16(24)28-17)10-4-9(2-3-11(10)20)27-15(29)12-6-26-14(7-25-12)30-8-19/h2-4,6-7,13H,5,8H2,1H3,(H2,24,28)(H,27,29)/t13-,17-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Zilovertamab vedotin MedChemExpress |Shelf Life: ≥12 months if stored properly.Ponatinib custom synthesis |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33225751 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|BACE1-IN-5 (Compound 15; 1-3 mg/kg; oral administration; for 2-6 hours; male ICR mice) treatment results in a significant and dose-dependent decrease of total Aβ, reduces total Aβ by 76% (4 hours) at a free brain concentration of 4.1 ng/mL (8.9 nM) at 1 mg/kg. BACE1-IN-5 demonstrats a Kp,uu value of 1.3 at 1 mg/kg (4 hours time point). At 3 mg/kg, a maximum Aβ reduction of 87% is achieved at a free brain concentration of 9.5 ng/mL (21 nM) .|Products are for research use only. Not for human use.|