Name: Cynomolgus CD3e/CD3ε Recombinant Protein (Fc Tag)
Synonyms: CD3 epsilon;CD3e antigen;CD3e antigen;epsilon polypeptide (TiT3 complex);CD3e molecule;epsilon (CD3-TCR complex);CD3e;CD3-epsilon;FLJ18683;T3E;T-cell antigen receptor complex;epsilon subunit of T3;T-cell surface antigen T3/Leu-4 epsilon chain;T-cell surface glycoprotein CD3 epsilon chain;TCRE
Expression host: HEK293 Cells
Sequence: Gln22-Asp117
Accesstion: Q95LI5
Species: Cynomolgus macaques
Mol_Mass: 38 kDa
AP_Mol_Mass: 38-55 kDa
Tag: C-Fc
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 100 mM Glycine, pH 7.5.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the
Reconstitution: Please refer to the printed manual for detailed information.
Background: T-cell surface glycoprotein CD3 epsilon chain, also known as CD3e, is a single-pass type I membrane protein. CD3e contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3e, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3e plays an essential role in T-cell development, and defects in CD3e gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3e genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.
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