Name: Mouse IL1RL1/ST2 Recombinant Protein (Fc Tag)

Synonyms: Interleukin-1 receptor-like 1;Lymphocyte antigen 84;Protein ST2;Protein T1;Il1rl1;DER4;Fit-1;IL-1 R4;IL-1RL1;IL-33R;Ly84;ST2L;ST2V;suppression of tumorigenicity 2

Expression host: HEK293 Cells

Sequence: Ser27-Ala337(Val192Ala)

Accesstion: P14719-2

Species: Mouse

Mol_Mass: 62.7 kDa

AP_Mol_Mass: 90-110 kDa

Tag: C-Fc

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin:

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Background: ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.

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