Name: Human Autotaxin/ENPP2 Recombinant Protein (aa 36-863, His Tag)
Synonyms: ATX;ATXFLJ26803;ATX-X;Autotaxin;autotaxin-t;EC 3.1.4.39;ectonucleotide pyrophosphatase/phosphodiesterase 2;E-NPP 2;ENPP2;LysoPLD;NPP2;PD-IALPHA;PDNP2;PDNP2NPP2
Expression host: HEK293 Cells
Sequence: Ala36-Ile863
Accesstion: AAH34961.1
Species: Human
Mol_Mass: 96 kDa
AP_Mol_Mass: 100-120 kDa
Tag: C-His
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mMPB,150mMNaCl,pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 – 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain.Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung.
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