Name: Human USP14 Recombinant Protein (His Tag)
Synonyms: Ubiquitin Carboxyl-Terminal Hydrolase 14;Deubiquitinating Enzyme 14;Ubiquitin Thioesterase 14;Ubiquitin-Specific-Processing Protease 14;USP14;TGT
Expression host: E.coli
Sequence: Asp91-Gln494
Accesstion: P54578
Species: Human
Mol_Mass: 48.5 kDa
AP_Mol_Mass: 52 kDa
Tag: N-His
Purity: > 85 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 20% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: Ubiquitin Carboxyl-Terminal Hydrolase 14 (USP14) belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 located in the cytoplasm is a proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. In addition, USP14 is indispensable for synaptic development and function at neuromuscular junctions, required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis.
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