Name: Human ASXL1 Recombinant Protein (GST Tag)
Synonyms: Putative Polycomb group protein ASXL1;Additional sex combs-like protein 1;ASXL1;KIAA0978;
Expression host: E.coli
Sequence: Lys1477-Arg1541
Accesstion: Q8IXJ9
Species: Human
Mol_Mass: 33.6 kDa
AP_Mol_Mass: 38 kDa
Tag: N-GST
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution: Not Applicable
Background: Putative Polycomb group protein ASXL1 involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). It acts as coactivator of RARA and RXRA through association with NCOA1. ASXL1 also acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters.
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