Name: Human SMAD1 Recombinant Protein (GST Tag)
Synonyms: Mothers Against Decapentaplegic Homolog 1;MAD Homolog 1;Mothers Against DPP Homolog 1;JV4-1;Mad-Related Protein 1;SMAD Family Member 1;Transforming Growth Factor-Beta-Signaling Protein 1;BSP-1;SMAD1;BSP1;MADH1;SMAD 1;SMAD1;hSMAD1;MADR1
Expression host: E.coli
Sequence: Met 1-Ser465
Accesstion: Q15797
Species: Human
Mol_Mass: 78.7 kDa
AP_Mol_Mass: 28&89 kDa
Tag: N-GST
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0 .Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the prin
Reconstitution: Please refer to the printed manual for detailed information.
Background: SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.
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