Name: Human Sialidase-1/NEU-1 Recombinant Protein (His Tag)
Synonyms: Sialidase-1;Acetylneuraminyl Hydrolase;G9 Sialidase;Lysosomal Sialidase;N-Acetyl-Alpha-Neuraminidase 1;NEU1;NANH
Expression host: HEK293 Cells
Sequence: Glu48-Leu415
Accesstion: Q99519
Species: Human
Mol_Mass: 41.3 kDa
AP_Mol_Mass: 39-50 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 50% Glycerol, pH 7.4.
Reconstitution: Not Applicable
Background: Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.
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