Name: Human SHMT1 Recombinant Protein (His Tag)
Synonyms: Serine Hydroxymethyltransferase Cytosolic;SHMT;Glycine Hydroxymethyltransferase;Serine Methylase;SHMT1
Expression host: HEK293 Cells
Sequence: Met3-Phe483
Accesstion: AAH07979.1
Species: Human
Mol_Mass: 53.9 kDa
AP_Mol_Mass: 55 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, 5% Trehalose, 5% Mannitol, 0.02% Tween80, pH 6.0.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer t
Reconstitution: Please refer to the printed manual for detailed information.
Background: Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to the NMDA receptor and this could be a mechanism behind Smith-Magenis syndrome.
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