Name: Human Sedoheptulokinase/SHPK Recombinant Protein (His Tag)
Synonyms: Sedoheptulokinase;SHK;Carbohydrate kinase-like protein;SHPK;CARKL
Expression host: HEK293 Cells
Sequence: Met 1-Ser478
Accesstion: AAH20543.1
Species: Human
Mol_Mass: 52.5 kDa
AP_Mol_Mass: 53 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 10% Glycerol, 3mM DTT, pH7.4.
Reconstitution: Not Applicable
Background: Sedoheptulokinase (SHPK) belongs to the FGGY kinase family, and is mainly located in cytoplasm. SHPK is strongly expressed in liver, kidney and pancreas. It is expressed at lower levels in placenta and heart, and very weakly expressed in lung and brain. SHPK catalyzes the chemical reaction: ATP + sedoheptulose = ADP + sedoheptulose 7-phosphatecan, It can transform sedoheptulose to sedoheptulose 7-phosphate in the condition of ATP, and acts as a modulator of macrophage activation through control of glucose metabolism. In addition, It also can be down-regulated by LPS.
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