Mol Biol Rev 77: 527539. 19. Jubelin G, Chavez CV, Taieb F, Banfield MJ, Samba-Louaka A, et al. Cycle inhibiting aspects are a expanding loved ones of functional cyclomodulins present in invertebrate and mammal bacterial pathogens. PLoS A single 4: e4855. 20. Crow A, Race PR, Jubelin G, Varela Chavez C, Escoubas JM, et al. Crystal structures of Cif from bacterial pathogens Photorhabdus luminescens and Burkholderia pseudomallei. PLoS 1 four: e5582. 21. Chavez CV, Jubelin G, Courties G, Gomard A, Ginibre N, et al. The cyclomodulin Cif of Photorhabdus luminescens inhibits insect cell proliferation and triggers host cell death by apoptosis. Microbes Infect 12: 12081218. 22. Yao Q, Cui J, Zhu Y, Wang G, Hu L, et al. A bacterial type III effector household uses the papain-like hydrolytic activity to arrest the host cell cycle. Proc Natl Acad Sci U S A 106: 37163721. 23. Felgner PL, Kayala MA, Vigil A, Burk C, Nakajima-Sasaki R, et al. A Burkholderia pseudomallei protein microarray reveals serodiagnostic and crossreactive antigens. Proc Natl Acad 23115181 Sci U S A 106: 1349913504. 24. Muangsombut V, Suparak S, hPTH (1-34) manufacturer Pumirat P, Damnin S, Vattanaviboon P, et al. Inactivation of Burkholderia pseudomallei bsaQ outcomes in decreased invasion efficiency and delayed escape of bacteria from endocytic vesicles. Arch Microbiol 190: 623631. 25. Sitthidet C, Stevens JM, Chantratita N, Currie BJ, Peacock SJ, et al. Prevalence and sequence diversity of a element expected for actin-based motility in organic populations of Burkholderia species. J Clin Microbiol 46: 24182422. 26. Alexeyev MF The pKNOCK series of broad-host-range mobilizable suicide vectors for gene knockout and targeted DNA insertion into the chromosome of gram-negative bacteria. Biotechniques 26: 824826, 828. 27. de Lorenzo V, Timmis KN Analysis and construction of steady phenotypes in gram-negative bacteria with Tn5- and Tn10-derived minitransposons. Methods Enzymol 235: 386405. 28. Heeb S, Blumer C, Haas D Regulatory RNA as mediator in GacA/ RsmA-dependent international handle of exoproduct formation in Pseudomonas fluorescens CHA0. J Bacteriol 184: 10461056. 29. Suparak S, Kespichayawattana W, Haque A, Easton A, Damnin S, et al. Multinucleated giant cell formation and apoptosis in infected host cells is mediated by Burkholderia pseudomallei kind III secretion protein BipB. J Bacteriol 187: 65566560. 30. Korbsrisate S, Tomaras AP, Damnin S, Ckumdee J, Srinon V, et al. Characterization of two distinct phospholipase C enzymes from Burkholderia pseudomallei. Microbiology 153: 19071915. 31. Kespichayawattana W, Rattanachetkul S, Wanun T, Utaisincharoen P, Sirisinha S Burkholderia pseudomallei induces cell fusion and actin-associated membrane protrusion: a possible mechanism for cell-to-cell spreading. Infect Immun 68: 53775384. 32. Stevens MP, Haque A, Atkins T, Hill J, Wood MW, et al. Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa form III secretion mutant in murine models of melioidosis. Microbiology 150: 26692676. 33. Hseu YC, Sung JC, Shieh BS, Chen SC Burkholderia pseudomallei infection induces the expression of apoptosis-related genes and proteins in mouse macrophages. J Microbiol Immunol Infect, In press. ten ~~ ~~ Hepatitis C virus causes chronic hepatitis in human. The virus generally escapes from host immune program and much more than 70% of infected patient maintains prolonged infection states. It results in liver cirrhosis and hepatocellular carcinoma. The virus is also reported to be involved in i