L deficits, or any drug intake. Family history of alcoholism, but not hypertension was noted in his father and brother. On admission, essential parameters showed marginal alcohol withdrawal sympathetic activity with pulse price of 96 beats/min and BP of 140/90 mm of Hg. His general physical along with the systemic examination revealed no other abnormal findings, except for fine tremors of both hands and mild hepatomegaly. Patient had preoccupations with alcohol, anxious mood with preserved cognitions, and grade4 insight. Right after alcohol CYP1 Inhibitor Molecular Weight detoxification, his BP had stabilized to 120/84 mm of Hg on day8 of admission. Electrocardiograph revealed no abnormalities. Hematological and biochemical investigations which include full blood count, blood glucose (105 mg/dl), blood urea (25 mg/dl), and serum creatinine (1.0 mg/dl) have been inside standard limits. Liver function tests have been regular except for elevated liver enzymes (gammaglutamyl transferase 96 units/L; serum glutamic oxaloacetic transaminase 120 units/L; serum glutamic pyruvic transaminase 56 units/L). His ultrasound abdomen showed mildly enlarged liver with grade2 fatty infiltration. Taking into consideration frequent relapses, patient, and spouse were explained concerning the nature of illness, and its numerous therapy modalities offered like DSF. Written informed consent for DSF therapy was taken along with a dose of 500 mg/day was initiated. Patient was discharged with DSF (500 mg/day), and multivitamin supplementation. At discharge, his important parameters had been steady with pulse of 86 beats/min, and BP of 130/80 mm of Hg. Compliance with medicines was ensured and supervised by his spouse. A fortnight later, patient complained of gradual onset occipital headache and giddiness with pulse rate of 86 bpm and BP of 146/100 mm of Hg. Life style modifications and dietary measures together with above prescribed drugs were advised. On week4 of DSF therapy, his complaints of headache, giddiness worsened, and BP improved to 170/110 mm of Hg. In view of recent inclusion of DSF, with the absence of prior health-related illnesses or drug history contributing to hypertension, possibility of drug induced (DSF) hypertension was suspected. Subsequently, DSF was lowered to 250 mg/ day and BP lowered to 150/96 mm of Hg per week later. DSF was further lowered to 125 mg/day following this observation and antihypertensive agents for example telmisartan 40 mg and hydrochlorothiazide 12.five mg/daywere also initiated on the Caspase 4 Inhibitor Storage & Stability physician’s suggestions. A month later (week8), patient reported with improved giddiness and physical fatigue with BP of 90/60 mm of Hg in spite of abstinent. Antihypertensive agents have been withdrawn and DSF was discontinued completely. Fortnight later (week10), patient had reached his premorbid levels of BP to 110/70 mm of Hg. Psycho education about health-related illness, life style modifications including standard workouts and dietary measures were advised. Six months later, patient had maintained comprehensive abstinence from alcohol at the same time as tobacco, and his BP was 130/80 mm of Hg [Figure 1].DISCuSSIONDSF, an alcohol deterring agent that’s somewhat nontoxic substance when administered alone, markedly alters the intermediary metabolism of alcohol. It acts by inhibiting aldehyde dehydrogenase, alcohol dehydrogenase and dopamine betahydroxylase (DBH).[9] DSF in conjunction with its two metabolites, diethyldithiocarbamate, and carbon disulphide inhibit DBH activity, a norepinephrine (NE) biosynthetic enzyme, which usually catalyzes the formation of NE from dopamin.