Name: Human FBPase 1/FBP1 Recombinant Protein (Human Cells, His Tag)
Synonyms: Fructose-1;6-bisphosphatase 1;D-fructose-1;6-bisphosphate 1-phosphohydrolase 1;FBP;FBPase 1
Expression host: HEK293 Cells
Sequence: Ala2-Gln338
Accesstion: P09467
Species: Human
Mol_Mass: 37.8 kDa
AP_Mol_Mass: 35-38 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 1mMEDTA, 10% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: Fructose-1;6-bisphosphatase 1(FBP1) is a homotetramer protein and belongs to the FBPase class 1 family. It involves in carbohydrate biosynthesis; gluconeogenesis pathway. FBP1 is a gluconeogenesis regulatory protein which catalyzes the hydrolysis of fructose 1;6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBP1 deficiency is associated with hypoglycemia and metabolic acidosis. FBP1 regulates mouse endogenous glucose production. FBP1 coupled with phosphofructokinase (PFK) takes part in the metabolism of pancreatic islet cells.
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