Product Name :
Win 18446
Description:
Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes.
CAS:
1477-57-2
Molecular Weight:
366.11
Formula:
C12H20Cl4N2O2
Chemical Name:
2,2-dichloro-N-[8-(2,2-dichloroacetamido)octyl]acetamide
Smiles :
O=C(NCCCCCCCCNC(=O)C(Cl)Cl)C(Cl)Cl
InChiKey:
FAOMZVDZARKPFJ-UHFFFAOYSA-N
InChi :
InChI=1S/C12H20Cl4N2O2/c13-9(14)11(19)17-7-5-3-1-2-4-6-8-18-12(20)10(15)16/h9-10H,1-8H2,(H,17,19)(H,18,20)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.AD 01 Cancer
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes.|Product information|CAS Number: 1477-57-2|Molecular Weight: 366.11|Formula: C12H20Cl4N2O2|Chemical Name: 2,2-dichloro-N-[8-(2,2-dichloroacetamido)octyl]acetamide|Smiles: O=C(NCCCCCCCCNC(=O)C(Cl)Cl)C(Cl)Cl|InChiKey: FAOMZVDZARKPFJ-UHFFFAOYSA-N|InChi: InChI=1S/C12H20Cl4N2O2/c13-9(14)11(19)17-7-5-3-1-2-4-6-8-18-12(20)10(15)16/h9-10H,1-8H2,(H,17,19)(H,18,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 10.87 mg/mL (29.69 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.18:0 mPEG2000 PE Metabolic Enzyme/Protease |Shelf Life: ≥12 months if stored properly.PMID:32809553 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|WIN 18446 (1 μM, 24 h) is able to suppress Stra8 expression in whole-testes cultures that contained both germ and somatic cells.|In Vivo:|Win 18446 (200 mg/kg, Orally for 4, 8, and 16 weeks) significantly reduces intratesticular concentrations of retinoic acid, severely impaired spermatogenesis, and caused infertility.|Products are for research use only. Not for human use.|