Product Name :
R-BC154 acetate
Description:
R-BC154 acetate is a selective fluorescent α9β1 integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity.
CAS:
Molecular Weight:
1212.37
Formula:
C57H65N9O15S3
Chemical Name:
acetic acid;5-[[1-[(3R, 5S)-1-(benzenesulfonyl)-5-[[(1S)-1-carboxy-2-[4-(pyrrolidine-1-carbonyloxy)phenyl]ethyl]carbamoyl]pyrrolidin-3-yl]triazol-4-yl]methylsulfamoyl]-2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonate
Smiles :
CC(O)=O.Guanfacine Autophagy CC[N+](CC)=C1C=C2OC3=CC(=CC=C3C(C3=CC=C(C=C3S([O-])(=O)=O)S(=O)(=O)NCC3=CN(N=N3)[C@H]3CN([C@@H](C3)C(=O)N[C@@H](CC3C=CC(=CC=3)OC(=O)N3CCCC3)C(O)=O)S(=O)(=O)C3C=CC=CC=3)=C2C=C1)N(CC)CC
InChiKey:
HZQNIDGYMDDNNP-MOVBADFXSA-N
InChi :
InChI=1S/C55H61N9O13S3.C2H4O2/c1-5-60(6-2)38-18-23-44-49(30-38)77-50-31-39(61(7-3)8-4)19-24-45(50)52(44)46-25-22-43(32-51(46)80(73,74)75)78(69,70)56-33-37-34-63(59-58-37)40-29-48(64(35-40)79(71,72)42-14-10-9-11-15-42)53(65)57-47(54(66)67)28-36-16-20-41(21-17-36)76-55(68)62-26-12-13-27-62;1-2(3)4/h9-11,14-25,30-32,34,40,47-48,56H,5-8,12-13,26-29,33,35H2,1-4H3,(H2-,57,65,66,67,73,74,75);1H3,(H,3,4)/t40-,47+,48+;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
R-BC154 acetate is a selective fluorescent α9β1 integrin antagonist.Palladium (II) Epigenetic Reader Domain R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity.|Product information|Molecular Weight: 1212.37|Formula: C57H65N9O15S3|Chemical Name: acetic acid;5-[[1-[(3R, 5S)-1-(benzenesulfonyl)-5-[[(1S)-1-carboxy-2-[4-(pyrrolidine-1-carbonyloxy)phenyl]ethyl]carbamoyl]pyrrolidin-3-yl]triazol-4-yl]methylsulfamoyl]-2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonate|Smiles: CC(O)=O.CC[N+](CC)=C1C=C2OC3=CC(=CC=C3C(C3=CC=C(C=C3S([O-])(=O)=O)S(=O)(=O)NCC3=CN(N=N3)[C@H]3CN([C@@H](C3)C(=O)N[C@@H](CC3C=CC(=CC=3)OC(=O)N3CCCC3)C(O)=O)S(=O)(=O)C3C=CC=CC=3)=C2C=C1)N(CC)CC|InChiKey: HZQNIDGYMDDNNP-MOVBADFXSA-N|InChi: InChI=1S/C55H61N9O13S3.C2H4O2/c1-5-60(6-2)38-18-23-44-49(30-38)77-50-31-39(61(7-3)8-4)19-24-45(50)52(44)46-25-22-43(32-51(46)80(73,74)75)78(69,70)56-33-37-34-63(59-58-37)40-29-48(64(35-40)79(71,72)42-14-10-9-11-15-42)53(65)57-47(54(66)67)28-36-16-20-41(21-17-36)76-55(68)62-26-12-13-27-62;1-2(3)4/h9-11,14-25,30-32,34,40,47-48,56H,5-8,12-13,26-29,33,35H2,1-4H3,(H2-,57,65,66,67,73,74,75);1H3,(H,3,4)/t40-,47+,48+;/m1.PMID:32996404 /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|R-BC154 acetate has 3 times greater affinities for α9β1 (Ki=12.7 nM) relative to α4β1 (Ki=38.0 nM) under Ca2+/Mg2+ conditions in human glioblastoma LN18 cell lines.|In Vivo:|R-BC154 acetate (10 mg/kg; i.v.) acts as an in vivo probe for bone marrow haemopoietic stem cells in mice.|Products are for research use only. Not for human use.|