Name: Human DFFA Recombinant Protein (His Tag)
Synonyms: DNA Fragmentation Factor Subunit Alpha;DNA Fragmentation Factor 45 kDa Subunit;DFF-45;Inhibitor of CAD;ICAD;DFFA;DFF1;DFF45;H13
Expression host: E.coli
Sequence: Met 1-Thr331
Accesstion: AAH07721.1
Species: Human
Mol_Mass: 38.7 kDa
AP_Mol_Mass: 40-50 kDa
Tag: N-His
Purity: > 85 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution: Not Applicable
Background: DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.
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