Product Name :
IACS-9571 hydrochloride
Description:
IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.
CAS:
2319611-93-1
Molecular Weight:
679.22
Formula:
C32H43ClN4O8S
Chemical Name:
N-(6-3-[4-(dimethylamino)butoxy]-5-propoxyphenoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)-3,4-dimethoxybenzene-1-sulfonamide; chlorohydrogen
Smiles :
Cl.CN(C)CCCCOC1C=C(C=C(C=1)OC1C=C2C(=CC=1NS(=O)(=O)C1C=C(OC)C(=CC=1)OC)N(C)C(=O)N2C)OCCC
InChiKey:
MOYQIQKWUIYJMN-UHFFFAOYSA-N
InChi :
InChI=1S/C32H42N4O8S.ClH/c1-8-14-42-22-16-23(43-15-10-9-13-34(2)3)18-24(17-22)44-30-21-28-27(35(4)32(37)36(28)5)20-26(30)33-45(38,39)25-11-12-29(40-6)31(19-25)41-7;/h11-12,16-21,33H,8-10,13-15H2,1-7H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.|Product information|CAS Number: 2319611-93-1|Molecular Weight: 679.22|Formula: C32H43ClN4O8S|Synonym:|ASIS-P040 hydrochloride|Chemical Name: N-(6-3-[4-(dimethylamino)butoxy]-5-propoxyphenoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)-3,4-dimethoxybenzene-1-sulfonamide; chlorohydrogen|Smiles: Cl.CN(C)CCCCOC1C=C(C=C(C=1)OC1C=C2C(=CC=1NS(=O)(=O)C1C=C(OC)C(=CC=1)OC)N(C)C(=O)N2C)OCCC|InChiKey: MOYQIQKWUIYJMN-UHFFFAOYSA-N|InChi: InChI=1S/C32H42N4O8S.ClH/c1-8-14-42-22-16-23(43-15-10-9-13-34(2)3)18-24(17-22)44-30-21-28-27(35(4)32(37)36(28)5)20-26(30)33-45(38,39)25-11-12-29(40-6)31(19-25)41-7;/h11-12,16-21,33H,8-10,13-15H2,1-7H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (184.Idarubicin custom synthesis 03 mM; Need ultrasonic and warming). H2O : 10 mg/mL (14.72 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.BIBR 1532 manufacturer |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|IACS-9571 Hydrochloride shows excellent cellular potency with EC50 of 50 nM.PMID:33063648 IACS-9571 Hydrochloride (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 Hydrochloride is a selective dual TRIM24/BRPF1 inhibitor (Kd=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 Hydrochloride does not interact with the BET sub-family of bromodomains, displaying greater than 7700-fold selectivity versus BRD4 (1, 2) relative to TRIM24.|References:|Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59(4):1440-54.Products are for research use only. Not for human use.|