Name: Human CHI3L1/YKL40 Recombinant Protein (His Tag)
Synonyms: Chitinase-3-Like protein 1;39 kDa Synovial Protein;Cartilage Glycoprotein 39;CGP-39;GP-39;hCGP-39;YKL-40;CHI3L1;ASRT7;DKFZp686N19119;FLJ38139;GP39;HC-gp39;HCGP-3P;YKL40;YYL-40
Expression host: HEK293 Cells
Sequence: Tyr22-Thr383
Accesstion: P36222
Species: Human
Mol_Mass: 41.5 kDa
AP_Mol_Mass: 46 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 2mM EDTA, pH8.5.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in
Reconstitution: Please refer to the printed manual for detailed information.
Background: Chitinase-3-Like Protein 1 (CHI3L1) belongs to the glycosyl hydrolase 18 family. CHI3L1 is expressed in activated macrophages, articular chondrocytes, synovial cells as well as in liver. It lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. CHI3L1 is thought to play a role in defense against pathogens, or in tissue remodeling, and in the capacity of cells to respond to and cope with changes in their environment. In addition, CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) which assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
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