Name: Human CD59 (C-6His)
Synonyms: 1F5 antigen;1F5;20 kDa homologous restriction factor;CD59 antigen;CD59 glycoprotein;CD59;HRF20;HRF-20;MACIF;MAC-IP;MIC11;MIC11MSK21;MIN1;MIN2;MIN3;MIRL;p18-20;16.3A5;EL32;FLJ38134;FLJ92039;G344
Expression host: HEK293 Cells
Sequence: Leu26-Asn102
Accesstion: P13987
Species: Human
Mol_Mass: 9.8 kDa
AP_Mol_Mass: 15-20 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: CD59, also known as membrane attack complex inhibition factor (MACIF), Protectin, 1F5 antigen, HRF-20 and MIRL, is an approximately 20 kDa GPI anchored glycoprotein that is an important regulator of the complement system in blood. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
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