Name: Human CCL16 Recombinant Protein
Synonyms: C-C Motif Chemokine 16;Chemokine CC-4;HCC-4;Chemokine LEC;IL-10-Inducible Chemokine;LCC-1;Liver-Expressed Chemokine;Lymphocyte and Monocyte Chemoattractant;LMC;Monotactin-1;MTN-1;NCC-4;Small-Inducible Cytokine A16;CCL16;ILINCK;NCC4;SCYA16
Expression host: E.coli
Sequence: Gln24-Gln120
Accesstion: O15467
Species: Human
Mol_Mass: 11.0 kDa
AP_Mol_Mass: 14 kDa
Tag: None
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed man
Reconstitution: Please refer to the printed manual for detailed information.
Background: CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines, showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocytes nor neutrophils. CCL16 has potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. CCL16ninduces a calcium flux in THP1 cells that can be desensitized by prior exposure to RANTES, suggesting that CCL16 and RANTES share the same receptor in THP1 cells.
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