Name: Human CC16 Recombinant Protein (His tag)
Synonyms: Uteroglobin;Clara cell phospholipid-binding protein;CCPBP;Clara cells 10 kDa secretory protein;CC10;Secretoglobin family 1A member 1;Urinary protein 1;UP-1;UP1;Urine protein 1;SCGB1A1;CCSP;UGB
Expression host: HEK293 Cells
Sequence: Glu22-Asn91
Accesstion: P11684
Species: Human
Mol_Mass: 9.9 kDa
AP_Mol_Mass: 10 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from sterile PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Uteroglobin is a small; non-glycosylated secreted protein of the secretoglobin superfamily. It is produced by the non-ciliated; non-mucous secretory cells that predominate in lung bronchioles (Clara cells); and other non-ciliated epithelia that communicate with the external environment. Expression is induced by steroid hormones such as estrogen; and enhanced by the non-steroid hormone prolactin. Human Uteroglobin cDNA encodes a 21 amino acid (aa) signal sequence and a 70 aa mature protein. The mature protein forms a disulfide-linked head-to-tail homodimer of 16 kDa. This homodimer is thought to form a binding pocket that binds hydrophobic ligands such as phospholipids; progesterone and retinols. Binding of fibronectin to Uteroglobin in the kidney is thought to protect against nephropathy; while binding of the lipocalin-1 receptor has been reported to suppress cancer cell motility and invasion.
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