Name: Human Cathepsin B/CTSB Recombinant Protein (His Tag)
Synonyms: Cathepsin B;APP Secretase;APPS;Cathepsin B1;CTSB;CPSB
Expression host: HEK293 Cells
Sequence: Arg18-Ile339
Accesstion: AAH10240.1
Species: Human
Mol_Mass: 36.9 kDa
AP_Mol_Mass: 34&38-50 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of PBS, 8% Sucrose, 0.05% Tween 80, pH7.4.
Reconstitution: Not Applicable
Background: Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes
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