Name: Human Caspase-10/CASP10 Recombinant Protein (His Tag)
Synonyms: Caspase-10;CASP-10;Apoptotic Protease Mch-4;FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2;FLICE2;ICE-Like Apoptotic Protease 4;CASP10;MCH4
Expression host: E.coli
Sequence: Val220-Ile480
Accesstion: Q92851-4
Species: Human
Mol_Mass: 30.1 kDa
AP_Mol_Mass: 33 kDa
Tag: C-His
Purity: > 70 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8% Sucrose, 1mM DTT, 0.05% Tween80, pH8.5.
Reconstitution: Not Applicable
Background: Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human caspases can be subdivided into three functional groups: cytokine activation (Caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). CASP10 cleaves and activates caspases 3 and 7, but itself is processed by caspase 8. Defects in CASP10 are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.
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