Name: Human Carboxypeptidase E/CPE Recombinant Protein (His Tag)
Synonyms: Carboxypeptidase E(CPE for short);Carboxypeptidase H;Enkephalin convertase;Prohormone-processing carboxypeptidase
Expression host: HEK293 Cells
Sequence: Arg42-Ser453
Accesstion: P16870
Species: Human
Mol_Mass: 47.2 kDa
AP_Mol_Mass: 50-60 kDa
Tag: C-His
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Histidine-HCl, 8% Sucrose, 2% Glycine, 20% Glycerol, 0.05% Tween 80, pH 6.5.
Reconstitution: Not Applicable
Background: The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. It is thought that membrane-associated CPE acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway. Defects in this protein are implicated in type II diabetes due to impaired glucose clearance and insulin resistance.
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