Name: Human Carboxypeptidase A1/CPA1 Recombinant Protein (His Tag)

Synonyms: Carboxypeptidase A1;CPA1;CPA

Expression host: HEK293 Cells

Sequence: Lys17-Tyr419

Accesstion: AAH05279.1

Species: Human

Mol_Mass: 46.6 kDa

AP_Mol_Mass: 44 kDa

Tag: C-His

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin:

Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mm NaCl, pH 7.5.

Reconstitution: Not Applicable

Background: Carboxypeptidase A1 (CPA1) is secreted as a pancreatic peptidase that comes from the precursor form of inactive procarboxypeptidase. CPA1 comprises a signal peptide, a pro region and a mature chain, and can be activated after cleavage of the pro peptide. It has a free C-terminal carboxyl group, with the preference of residues with aromatic or branched aliphatic side chains. CPA1 cleaves the C-terminal amide or ester bond of peptides and involves in zymogen inhibition. Three different forms of human pancreatic proCarboxypeptidase A have been isolated. In contrast to procarboxypeptidase B which was always secreted by the pancreas as a monomer, proCarboxypeptidase A occurs as a monomer and/or associated to one or two functionally different proteins, such as zymogen E.

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