Name: Human Carbonic Anhydrase 8/CA8 Recombinant Protein (His Tag)
Synonyms: Carbonic Anhydrase-Related Protein;CARP;Carbonic Anhydrase VIII;CA-VIII;CA8;CALS;CAMRQ3;MGC120502;MGC99509
Expression host: E.coli
Sequence: Ala2-Gln290
Accesstion: P35219
Species: Human
Mol_Mass: 34.0 kDa
AP_Mol_Mass: 40 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 1mM DTT, pH 8.5.
Reconstitution: Not Applicable
Background: Carbonic Anhydrase 8 (CA8) belongs to the alpha-Carbonic Anhydrase family. Alpha-Carbonic Anhydrase is a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Because CA8 has some sequence similarity with other known Carbonic Anhydrase genes, it was firstly called as CA-related protein. Nevertheless, CA8 does not have a Carbonic Anhydrase catalytic activity. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3), which is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation.
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