Name: Human Carbonic Anhydrase 4/CA4 Recombinant Protein (His Tag)
Synonyms: Carbonic Anhydrase 4;Carbonate Dehydratase IV;Carbonic Anhydrase IV;CA-IV;CA4;CAIV;Car4;RP17
Expression host: E.coli
Sequence: Ala19-Lys283
Accesstion: P22748
Species: Human
Mol_Mass: 31.4 kDa
AP_Mol_Mass: 30 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, pH 8.5.
Reconstitution: Not Applicable
Background: Carbonic Anhydrase 4 (CA4) belongs to the alpha-Carbonic Anhydrase family. Alpha-Carbonic Anhydrase is a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Carbonic Anhydrase 4 is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Carbonic Anhydrase 4 may stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It may have a role in inherited renal abnormalities of bicarbonate transport. Furthermore, Carbonic Anhydrase 4 is essential for acid overload removal from the retina and retina epithelium and acid release in the choriocapillaris.
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