Name: Human Calcitonin/CALCA Recombinant Protein (His Tag, E. coli)

Synonyms: Calcitonin;Katacalcin;Calcitonin Carboxyl-Terminal Peptide;CCP;PDN-21;CALCA;CALC1

Expression host: E.coli

Sequence: Tyr58-Asn141

Accesstion: P01258

Species: Human

Mol_Mass: 10.5 kDa

AP_Mol_Mass: 14-20 kDa

Tag: C-His

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin:

Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 50% Glycerol, pH 7.4.

Reconstitution: Not Applicable

Background: Calcitonin is a secreted protein which belongs to the Calcitonin family. Calcitonin is cleaved into the following two chains: Calcitonin and Katacalcin. Katacalcin is a potent plasma calcium-lowering peptide. Calcitonin is a 32-amino acid linear polypeptide hormone. Calcitonin acts to reduce blood calcium (Ca2+); opposing the effects of parathyroid hormone (PTH). Its importance in humans has not been as well established as its importance in other animals; as its function is usually not significant in the regulation of normal calcium homeostasis. Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

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