Name: Rhesus macaque IFNAR1 Recombinant Protein (His Tag)
Synonyms: Alpha-type antiviral protein;AVP;beta-type antiviral protein;CRF2-1;Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC;IFN-alpha/beta R1;IFN-alpha/beta receptor 1;IFN-alpha-REC;IFNAR;IFNAR1;IFN-aR1;IFNBR;IFNbR1;IFN-bR1;IFN-R-1
Expression host: HEK293 Cells
Sequence: Ala25-Lys437
Accesstion: XP_005548864.1
Species: Rhesus macaque
Mol_Mass: 48.4 kDa
AP_Mol_Mass: 70-120 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Interferon?alpha/beta receptor 1 (IFN? alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
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