Name: Mouse TRAIL R2/TNFRSF10B Recombinant Protein (Fc Tag)
Synonyms: Tumor Necrosis Factor Receptor Superfamily Member 10B;Death Receptor 5;TNF-Related Apoptosis-Inducing Ligand Receptor 2;TRAIL Receptor 2;TRAIL-R2;CD262;TNFRSF10B;DR5;KILLER;TRAILR2;TRICK2;ZTNFR9
Expression host: HEK293 Cells
Sequence: Asn53-Ser177
Accesstion: Q9QZM4
Species: Mouse
Mol_Mass: 40.9 kDa
AP_Mol_Mass: 50-75 kDa
Tag: C-Fc
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual
Reconstitution: Please refer to the printed manual for detailed information.
Background: Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ER stress-induced apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis.
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