Name: Mouse TPBG/5T4 (C-6His)
Synonyms: 5T4 Protein;Human;5T4AG Protein;Human;M6P1 Protein;Human;WAIF1 Protein;Human
Expression host: HEK293 Cells
Sequence: Ser32-Ser361
Accesstion: Q9Z0L0
Species: Mouse
Mol_Mass: 36.6 kDa
AP_Mol_Mass: 50-70 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution: Not Applicable
Background: Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
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