Name: Mouse PCSK9/NARC1 Recombinant Protein (His Tag)
Synonyms: Proprotein Convertase Subtilisin/Kexin Type 9;Neural Apoptosis-Regulated Convertase 1;NARC-1;Proprotein Convertase 9;PC9;Subtilisin/Kexin-Like Protease PC9;Pcsk9;Narc1;FH3;HCHOLA3;Narc1
Expression host: HEK293 Cells
Sequence: Gln35-Gln155&Ser156-Gln694
Accesstion: Q80W65
Species: Mouse
Mol_Mass: 14&58.2 kDa
AP_Mol_Mass: 19&60 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4.
Reconstitution: Not Applicable
Background: Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis.PCSK9 also plays a role in neural development.
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