Name: Human BAG2 Recombinant Protein (His Tag)
Synonyms: BAG Family Molecular Chaperone Regulator 2;BAG-2;Bcl-2-Associated Athanogene 2;BAG2
Expression host: E.coli
Sequence: Met 1-Asn211
Accesstion: O95816
Species: Human
Mol_Mass: 25.9 kDa
AP_Mol_Mass: 25-30 kDa
Tag: N-His
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, 1mM DTT, 10% Glycerol, pH8.0.
Reconstitution: Not Applicable
Background: BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is a important component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex. In mammalian cells BAG1, BAG2, and BAG3 bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
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