Name: Mouse Carbonic Anhydrase 4/CA4 Recombinant Protein (aa 18-277, His Tag)
Synonyms: CA4;CAIV;CA-IV;Car4;Carbonate dehydratase IV;Carbonic Anhydrase 4;Carbonic Anhydrase IVRP17;carbonic dehydratase IV;EC4.2.1.1;retinitis pigmentosa 17;RP17
Expression host: HEK293 Cells
Sequence: Glu18-Ser277
Accesstion: Q64444
Species: Mouse
Mol_Mass: 30.5 kDa
AP_Mol_Mass: 36 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Reconstitution: Not Applicable
Background: Carbonic Anhydrase 4(CA4) is an enzyme that belongs to the alpha-Carbonic Anhydrase family. CA4 consists of a signal peptide (residues1-17), an ectodomain (residues18-277) and a propeptide (residues278-305), which is removed in the mature form. it is predominantly expressed in the embryo. CA4 can catalyzes the reversible reaction of CO2+H2O=HCO3-+H+, and stimulates the sodium/bicarbonate transporter activity of SLC4A4. Studies have shown that this protein have a role in inherited renal abnormalities of bicarbonate transport. Alpha-Carbonic Anhydrase family participate in avariety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor. They show extensive diversity in tissue is attribution and in their sub cellular localization.
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