Name: Mouse APCS/SAP Recombinant Protein (His Tag)
Synonyms: APCS;PTX2;SAP;9.5S alpha-1-glycoprotein;Serum amyloid P;MGC88159;PTX2serum amyloid P-component;SAP pentaxin-related
Expression host: HEK293 Cells
Sequence: Gln21-Asp224
Accesstion: P12246
Species: Mouse
Mol_Mass: 24.9 kDa
AP_Mol_Mass: 28-32 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 50mM Imidazole, 5% Trehalose, 20% Glycerol, pH8.0.
Reconstitution: Not Applicable
Background: Pentraxin 2 (PTX2), also known as Serum amyloid P (SAP), is a highly conserved, naturally circulating plasma protein and a soluble pattern recognition receptor of the innate immune system. The unique binding activities indicated that it may play an important role in the removal of damaged tissue. PTX2 belongs to the pentraxin family, is universally present in amyloid deposits. Mouse with targeted deletion of the PTX2 gene shows retarded and reduced induction of experimental reactive systemic (AA type) amyloidosis confirmed that it does indeed contribute to pathogenesis of amyloidosis and is a valid therapeutic target. In recent discovery, PTX2 can be used as a powerful antifibrotic agent to regulate certain monocyte differentiation states.
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