Name: Macaca nemestrina PCSK9/ProRecombinant Protein Convertase 9 Recombinant Protein (His Tag)
Synonyms: Proprotein Convertase Subtilisin/Kexin Type 9;Proprotein Convertase 9;PC9;Subtilisin/Kexin-Like Protease PC9;PCSK9
Expression host: HEK293 Cells
Sequence: Gln31-Gln152&Ser153-Gln692
Accesstion: A8T662
Species: Macaca nemestrina
Mol_Mass: 14&59 kDa
AP_Mol_Mass: 16-21&55-77 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 0.1M Arg, 0.1M Glu, 20% glycerol, 0.01% tween20, 5% Trehalose, pH 6.0.
Reconstitution: Not Applicable
Background: Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.
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