Name: Klebsiella pneumoniae NEO Recombinant Protein
Synonyms: Aminoglycoside 3′-phosphotransferase;APH(3′)-II;APH(3′)II;Kanamycin kinase type II;Neomycin-kanamycin phosphotransferase type II;neo
Expression host: E.coli
Sequence: Met1-Phe264
Accesstion: P00552
Species: Klebsiella pneumoniae
Mol_Mass: 29 kDa
AP_Mol_Mass: 26-30 kDa
Tag: None
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 6%Trehalose, 4%Mannitol, 0.05%Tween80, PH8.0.
Reconstitution: Not Applicable
Background: Aminoglycoside 3′-phosphotransferase (APH(3′)), also known as aminoglycoside kinase, is an aminoglycoside-modifying enzyme and widely presented in resistant bacteria. These ATP-dependent enzymes phosphorylate the 3′-hydroxyl of a variety of aminoglycosides including kanamycins, neomycins, paromomycins, neamine, ribostamycin, geneticin, and paromamine. These phosphorylated aminoglycosides fail to bind to their respective ribosomal binding sites with high affinity; hence resistance is conferred to the drugs that are phosphorylated. APH(3′) is primarily found in certain species of gram-positive bacteria.
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