Name: Human ATG5 Recombinant Protein
Synonyms: Autophagy protein 5;APG5-like;Apoptosis-specific protein;APG5L;ASP;ATG5;
Expression host: E.coli
Sequence: Met 1-Asp275
Accesstion: Q9H1Y0
Species: Human
Mol_Mass: 32.4 kDa
AP_Mol_Mass: 33 kDa
Tag: None
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 0.2M NaCl, 1mM DTT, 40% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic cells. It is activated by ATG7, conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate complex detaches from the membrane immediately before or after autophagosome formation is completed. ATG5 plays an important role in the apoptotic process, possibly within the modified cytoskeleton.
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