Name: Human Vaspin/SerpinA12 Recombinant Protein (GST Tag)
Synonyms: Serpin A12;OL-64;Visceral Adipose Tissue-Derived Serine Protease Inhibitor;Vaspin;Visceral Adipose-Specific Serpin;SERPINA12
Expression host: E.coli
Sequence: Leu21-Lys414
Accesstion: Q8IW75
Species: Human
Mol_Mass: 71.4 kDa
AP_Mol_Mass: 72 kDa
Tag: N-GST
Purity: > 80 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 160mM NaCl, 0.2mM PMSF, 1mM DTT, 10% Glycerine, pH 7.2 .
Reconstitution: Not Applicable
Background: Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three β-sheets; nine α-helices; and one central loop; the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity; insulin resistance; and glucose metabolism. These findings suggest a potential clinical use for Vaspin in ameliorating certain aberrations seen in the obesity metabolic syndrome.
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