Name: Human VAP-1/AOC3 Recombinant Protein (His Tag)
Synonyms: Membrane primary amine oxidase;Copper amine oxidase;HPAO;Semicarbazide-sensitive amine oxidase;SSAO;Vascular adhesion protein 1;VAP-1;AOC3;VAP1
Expression host: HEK293 Cells
Sequence: Arg28-Asn763
Accesstion: Q16853
Species: Human
Mol_Mass: 82.6 kDa
AP_Mol_Mass: 90-110 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, pH 8.0.
Reconstitution: Not Applicable
Background: Vascular adhesion protein-1(VAP-1) is a copper amine oxidase with a topaquinone cofactor.VAP-1 is a type II integral membrane protein; but a soluble form of the enzyme is present in human serum; and its level increases in diabetes and some inflammatory liver diseases. VAP-1 catalyzes the oxidative deamination of small primary amines such as methylamine; benzylamine; and aminoacetone in a reaction that produces an aldehyde; ammonia; and H2O2. VAP-1 vascular expression is regulated at sites of inflammation through its release from intracellular granules in which the protein is stored. The adhesive function of VAP-1 has been demonstrated in studies showing that the protein is important for the adherence of certain lymphocyte subtypes to inflamed endothelial tissues. VAP-1 mediated adhesion is involved in the process of leukocyte extravasation; an important feature of inflammatory responses. VAP-1 is considered to be a therapeutic target for diabetes; oxidative stress; and inflammatory diseases.
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