Name: Human UCHL3/UCH-L3 Recombinant Protein (His Tag)
Synonyms: Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3;UCH-L3;Ubiquitin Thioesterase L3;UCHL3
Expression host: E.coli
Sequence: Met 1-Ala230
Accesstion: P15374
Species: Human
Mol_Mass: 27.3 kDa
AP_Mol_Mass: 25 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 150mM NaCl, 1mM DTT, 50% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: Ubiquitin Carboxyl-Terminal Hydrolases (UCHs) are a family of cysteine hydrolases. They catalyze the hydrolysis of amides, thioesters and esters, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin. Up regulation of UCHL3 is associated with uterine cervical neoplasms. UCHL3 is implicated in age related cognitive disorders. UCHL3 also promotes adipogenesis and insulin signaling. In mice, UCHL3 knockout have been shown to be resistant to diet-induced obesity.
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