Name: Human Ube2H Recombinant Protein (GST Tag)
Synonyms: Ubiquitin-Conjugating Enzyme E2 H;UbcH2;Ubiquitin Carrier Protein H;Ubiquitin-Conjugating Enzyme E2-20K;Ubiquitin-Protein Ligase H;UBE2H;E2-20K;GID3;UBC8;UBCH;UBCH2
Expression host: E.coli
Sequence: Met 1-Leu183
Accesstion: P62256
Species: Human
Mol_Mass: 47.0 kDa
AP_Mol_Mass: 50 kDa
Tag: N-GST
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5.
Reconstitution: Not Applicable
Background: Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes; or E1s; ubiquitin-conjugating enzymes; or E2s; and ubiquitin-protein ligases; or E3s. It has been shown to conjugate ubiquitin to histone H2A in an E3 dependent manner in vitro. UBE2H is the human homolog to the yeast DNA repair gene RAD6; which is induced by DNA damaging reagents. UBE2H has been associated with cancer-induced cachexia and with the regulation of sepsis-induced muscle proteolysis.
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